GLYCATION OF BETA AMYLOIDS AND THEIR CONTRIBUTION TO INSULIN RESISTANCE IN TYPE 2 DIABETES MELLITUS

Type 2 Diabetes Mellitus (T2DM) is metabolic disorder that afflicts 200,000 Americans per year and a total of 463 million people globally. Due to significant dietary changes that increase intake of fats and sugars, 9.5% of Americans over 18 years old begin to develop pre-diabetes old and left untreated should expect to develop T2DM within 5 years. Although researchers have been able to link diet, genetic factors and epigenetic factors to T2DM, the mechanism through which Type 2 Diabetes develops remains elusive. Diabetic patients experience a wide range of symptoms, the most significant of which are impaired insulin action, hyperlipidemia, and chronic inflammation. Recently researchers have observed that beta amyloid accumulation can cause insulin resistance both directly and indirectly. Beta amyloids can bind to cell surface and cause chronic inflammation by over-stimulating the JAK/STAT pathway as well as cause free fatty acid (FFA) accumulation within cells through CD36 activation caused by Ca2+ influx. Glycation, the non-enzymatic addition of glucose molecules to beta amyloids, also can contribute significantly to the accumulation of beta amyloids in the body. Beta amyloids in high glucose environments appear to exhibit reduced clearance for in vivo models similar to those of glycosylated beta amyloids due to London and Sweden mutation exhibiting patients. This information suggests that glycated beta amyloids show decreased elimination compared to non-glycated beta amyloids. In this paper, we explore the potential accumulation of beta amyloids and glycated beta amyloids through a multi-compartment model sensitivity analysis that adjusts the glycation rate constant and perfusion of glucose between the intestines and visceral adipose tissue. From our results we conclude that the glycation reaction rate of beta amyloids has a greater variability on the overall accumulation of glycated beta amyloids than the concentration of glucose in the organ compartments. This variability is dependent on whether the patient consumes high glycemic index (GI) meals or low GI meals. However, it is unknown if such small changes to blood volume glucose concentrations will result in insulin resistance potential. Future development of the model should implement the influx of beta amyloids into tissue volume compartments via primarily receptors for advanced glycation end products (RAGEs)

Rolling Locomotion of Cable-Driven Soft Spherical Tensegrity Robots

Soft spherical tensegrity robots are novel steerable mobile robotic platforms that are compliant, lightweight, and robust. The geometry of these robots is suitable for rolling locomotion, and they achieve this motion by properly deforming their structures using carefully chosen actuation strategies. The objective of this work is to consolidate and add to our research to date on methods for realizing rolling locomotion of spherical tensegrity robots. To predict the deformation of tensegrity structures when their member forces are varied, we introduce a modified version of the dynamic relaxation technique and apply it to our tensegrity robots. In addition, we present two techniques to find desirable deformations and actuation strategies that would result in robust rolling locomotion of the robots. The first one relies on the greedy search that can quickly find solutions, and the second one uses a multigeneration Monte Carlo method that can find suboptimal solutions with a higher quality. The methods are illustrated and validated both in simulation and with our hardware robots, which show that our methods are viable means of realizing robust and steerable rolling locomotion of spherical tensegrity robots

Nonlinear Control of Autonomous Flying Cars with Wings and Distributed Electric Propulsion

Hybrid vertical take-off and landing vehicles (VTOL) with lift production from wings and distributed propulsive system present unique control challenges. Existing methods tend to stitch and switch different controllers specially designed for fixed-wing aircraft or multicopters. In this paper, we present a unified framework for designing controllers for such winged VTOL vehicles that are commonly found in recent flying car models. The proposed method is broken down into nonlinear control of both position and attitude with forces and moments as inputs, and real-time control allocation that integrates distributed propulsive actuation with conventional control surface deflection. We also present a strategy that avoids saturation of distributed propulsion control inputs. The effectiveness of the proposed framework is demonstrated through simulation and closed-loop flight experiment with our winged VTOL flying car prototype

Monocular-Based Pose Determination of Uncooperative Space Objects

Vision-based methods to determine the relative pose of an uncooperative orbiting object are investigated in applications to spacecraft proximity operations, such as on-orbit servicing, spacecraft formation flying, and small bodies exploration. Depending on whether the object is known or unknown, a shape model of the orbiting target object may have to be constructed autonomously in real-time by making use of only optical measurements. The Simultaneous Estimation of Pose and Shape (SEPS) algorithm that does not require a priori knowledge of the pose and shape of the target is presented. This makes use of a novel measurement equation and filter that can efficiently use optical flow information along with a star tracker to estimate the target's angular rotational and translational relative velocity as well as its center of gravity. Depending on the mission constraints, SEPS can be augmented by a more accurate offline, on-board 3D reconstruction of the target shape, which allows for the estimation of the pose as a known target. The use of Structure from Motion (SfM) for this purpose is discussed. A model-based approach for pose estimation of known targets is also presented. The architecture and implementation of both the proposed approaches are elucidated and their performance metrics are evaluated through numerical simulations by using a dataset of images that are synthetically generated according to a chaser/target relative motion in Geosynchronous Orbit (GEO)

Monocular-Based Pose Determination of Uncooperative Known and Unknown Space Objects

In order to support spacecraft proximity operations, such as on-orbit servicing and spacecraft formation flying, several vision-based techniques exist to determine the relative pose of an uncooperative orbiting object with respect to the spacecraft. Depending on whether the object is known or unknown, a shape model of the orbiting target object may have to be constructed autonomously by making use of only optical measurements. In this paper, we investigate two vision-based approaches for pose estimation of uncooperative orbiting targets: one that is general and versatile such that it does not require a priori knowledge of any information of the target, and the other one that requires knowledge of the target's shape geometry. The former uses an estimation algorithm of translational and rotational dynamics to sequentially perform simultaneous pose determination and 3D shape reconstruction of the unknown target, while the latter relies on a known 3D model of the target's geometry to provide a point-by-point pose solution. The architecture and implementation of both methods are presented and their achievable performance is evaluated through numerical simulations. In addition, a computer vision processing strategy for feature detection and matching and the Structure from Motion (SfM) algorithm for on-board 3D reconstruction are also discussed and validated by using a dataset of images that are synthetically generated according to a chaser/target relative motion in Geosynchronous Orbit (GEO)

Robotic Herding of a Flock of Birds Using an Unmanned Aerial Vehicle

In this paper, we derive an algorithm for enabling a single robotic unmanned aerial vehicle to herd a flock of birds away from a designated volume of space, such as the air space around an airport. The herding algorithm, referred to as the m-waypoint algorithm, is designed using a dynamic model of bird flocking based on Reynolds’ rules. We derive bounds on its performance using a combination of reduced-order modeling of the flock's motion, heuristics, and rigorous analysis. A unique contribution of the paper is the experimental demonstration of several facets of the herding algorithm on flocks of live birds reacting to a robotic pursuer. The experiments allow us to estimate several parameters of the flocking model, and especially the interaction between the pursuer and the flock. The herding algorithm is also demonstrated using numerical simulations

Monocular-Based Pose Determination of Uncooperative Space Objects

Vision-based methods to determine the relative pose of an uncooperative orbiting object are investigated in applications to spacecraft proximity operations, such as on-orbit servicing, spacecraft formation flying, and small bodies exploration. Depending on whether the object is known or unknown, a shape model of the orbiting target object may have to be constructed autonomously in real-time by making use of only optical measurements. The Simultaneous Estimation of Pose and Shape (SEPS) algorithm that does not require a priori knowledge of the pose and shape of the target is presented. This makes use of a novel measurement equation and filter that can efficiently use optical flow information along with a star tracker to estimate the target's angular rotational and translational relative velocity as well as its center of gravity. Depending on the mission constraints, SEPS can be augmented by a more accurate offline, on-board 3D reconstruction of the target shape, which allows for the estimation of the pose as a known target. The use of Structure from Motion (SfM) for this purpose is discussed. A model-based approach for pose estimation of known targets is also presented. The architecture and implementation of both the proposed approaches are elucidated and their performance metrics are evaluated through numerical simulations by using a dataset of images that are synthetically generated according to a chaser/target relative motion in Geosynchronous Orbit (GEO)

Nonlinear Control of Autonomous Flying Cars with Wings and Distributed Electric Propulsion

Hybrid vertical take-off and landing vehicles (VTOL) with lift production from wings and distributed propulsive system present unique control challenges. Existing methods tend to stitch and switch different controllers specially designed for fixed-wing aircraft or multicopters. In this paper, we present a unified framework for designing controllers for such winged VTOL vehicles that are commonly found in recent flying car models. The proposed method is broken down into nonlinear control of both position and attitude with forces and moments as inputs, and real-time control allocation that integrates distributed propulsive actuation with conventional control surface deflection. We also present a strategy that avoids saturation of distributed propulsion control inputs. The effectiveness of the proposed framework is demonstrated through simulation and closed-loop flight experiment with our winged VTOL flying car prototype

Controllability and Design of Unmanned Multirotor Aircraft Robust to Rotor Failure

A new design method for multi-rotor aircraft with distributed electric propulsion is presented to ensure a property of robustness against rotor failure from the control perspective. Based on the concept of null controllability, a quality measure is derived to evaluate and quantify the performance of a given design with the consideration of rotor failure. An optimization problem whose cost function is based on the quality measure is formulated and its optimal solution identifies a set of optimal design parameters that maximizes an aircraft’s ability to control its attitude and hence its position. The effectiveness of the proposed design procedure is validated through the results of experimentation with the Autonomous Flying Ambulance model being developed at Caltech’s Center for Autonomous Systems and Technologies

Robotic Herding of a Flock of Birds Using an Unmanned Aerial Vehicle

In this paper, we derive an algorithm for enabling a single robotic unmanned aerial vehicle to herd a flock of birds away from a designated volume of space, such as the air space around an airport. The herding algorithm, referred to as the m-waypoint algorithm, is designed using a dynamic model of bird flocking based on Reynolds’ rules. We derive bounds on its performance using a combination of reduced-order modeling of the flock's motion, heuristics, and rigorous analysis. A unique contribution of the paper is the experimental demonstration of several facets of the herding algorithm on flocks of live birds reacting to a robotic pursuer. The experiments allow us to estimate several parameters of the flocking model, and especially the interaction between the pursuer and the flock. The herding algorithm is also demonstrated using numerical simulations